The presented results could be of interest to clinicians managing wounds. Some important differences in the antimicrobial potential of investigated materials have been found. Results revealed that its activity against Staphylococcus aureus was comparable to the most active wound dressings impregnated with silver or inadine. In addition, we also tested the anti-staphylococcal activity of a biopolymer material impregnated with lysostaphin. The Medisorb Silver Pad, containing silver, and Bactigras, which contains chlorhexidine acetate, revealed much lower antimicrobial activity, particularly noticeable in the time-killing assay. High activity against all tested bacteria, but only in the disc diffusion assay, was observed for Algivon, which contains manuka honey. However, 24 hours' includation was required for complete elimination of the cells of this bacteria strain. High effectiveness against Escherichia coli was also demonstrated for Silvercel. Even when the dressing does contact the wound bed, it is important to maximize exposure of. In the case of Aquacel Ag, 24 hours' incubation resulted in complete elimination of the cells of both Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa.The Escherichia coli cells were killed after only four hours' treatment. AQUACEL Ag & Mepilex Ag dressings: Silver availability15. Silvercel, Aquacel Ag and Melgisorb Ag, which also contain silver, also exhibited a satisfactory level of activity. The same results were obtained for a povidone-iodine containing dressing, Inadine, though its activity was lower in the disc diffusion assay. Incubation for four hours of a 10x10mm2 piece of this material in 10ml cells suspension (concentration: 109-1010CFU/ml) resulted in complete elimination of bacteria of all four strains tested. ![]() The materials were tested against four reference strains of bacteria: Staphylococcus aureus (PCM 2051), Staphylococcus epidermidis (PCM 2118), Pseudomonas aeruginosa (ATCC 27853), and Escherichia coli (K12), using the disc diffusion-like method and a time-killing assay.įor both experiments, the highest activity against all four tested strains of bacteria was observed in the case of Mepilex Ag, which contains silver as an antibacterial agent. The efficacy and adverse effects of the Ag dressings revealed differences that should be considered by clinicians during wound management.The aim of our study was to examine the antimicrobial potential of eight selected, commercially available wound dressings containing different antimicrobial agents: silver, chlorhexidine acetate, povidone-iodine, and manuka honey. aeruginosa, respectively, whereas the cytotoxicity was similar to those of Aquacel Ag and Algisite Ag. The use of Mepilex Ag after pediatric tracheotomy reduces the occurrence of postoperative peristomal pressure ulcers. No comorbidities were associated with postoperative ulcer formation in either cohort. PolyMem Ag showed the lowest Ag release, and the antibacterial activity classified as "significant" or "no activity" for S. When Mepilex Ag was used to pad the tracheotomy site, no peristomal skin breakdown occurred (P 0.02). However, the antibacterial activity was classified as "significant" or "no activity" for P. Mepilex Ag showed the highest release of Ag, and the cytotoxicity was the highest among the Ag dressings. Aquacel Ag and Algisite Ag showed higher antibacterial activity and cytotoxic effects, which were supported by the higher Ag release. Biohesive Ag was regarded as a slow-release Ag dressing, showing the lowest cytotoxicity, while the antibacterial activity was classified as "strong" or "significant" against the two species of bacteria. The cytotoxicity was not a monotonic function of the antibacterial activity among the Ag dressings and could not be simply explained by Ag-release properties. ![]() Mepilex Silicone Foam Dressing 5cm x 5cm Box of 5. The cytotoxicity was evaluated using V79 cells, by an extraction method. PLUS AQUACEL Ag EXTRA helps protect wounds from infection by killing a broad. The antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa were accessed by a disc diffusion test. The release of Ag was investigated in cell culture medium at immersion periods of 6, 24, and 48 hours. This study evaluated the in vitro antibacterial activity and cytotoxicity of various commercially available silver-containing dressings (Ag dressing).īiohesive Ag (hydrocolloid, silver sulfadiazine), Aquacel® Ag (nonwoven fabric, ionic silver ), Algisite™ Ag (nonwoven fabric, Ag), Mepilex® Ag (foam, silver sulfate), and PolyMem® Ag (foam, nanocrystalline silver) were tested for characteristics of Ag release, antibacterial activity, and cytotoxicity.
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